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phenobarbital improves toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers could improve the metabolism of ifosfamide to its Energetic alkylating metabolites.Barbiturates may impair the psychological and/or Bodily skills expected for that overall performance of doubtless harmfu